Menthol, identified by the CAS number 89-78-1, is a cyclic terpene alcohol that is primarily derived from peppermint oil or can be synthesized from thymol. It is widely recognized for its characteristic minty aroma and cooling sensation, which is attributed to its interaction with the TRPM8 receptor on sensory nerve endings. This interaction leads to a perception of cold without a change in actual temperature, making menthol a popular ingredient in various applications, including medicinal and cosmetic products.
Chemical Properties and Uses
Chemical Structure: Menthol has the empirical formula C10H20O and is classified as a monocyclic monoterpene alcohol. It appears as a white crystalline solid with a peppermint-like odor.
Applications: Menthol is utilized in a variety of products, including:
Topical Analgesics: It is commonly found in creams and ointments designed to relieve minor aches and pains, as it acts as a counterirritant.
Cough and Cold Remedies: Menthol is included in throat lozenges and cough syrups for its soothing properties.
Flavoring Agent: It is used to impart a mint flavor in candies, gums, and other food products.
Biological Activity
Menthol exhibits several biological activities, including:
Analgesic Properties: It can provide relief from pain and irritation by inducing a cooling sensation.
Antimicrobial Effects: Studies have shown that menthol possesses antibacterial and antifungal properties, making it useful in various formulations.
Safety and Toxicity
While menthol is generally safe when used appropriately, it can be harmful in large quantities. Ingestion of pure menthol can lead to poisoning, necessitating immediate medical attention. It is important to follow dosage guidelines, especially in topical applications, to avoid skin irritation or adverse reactions.
In summary, menthol (CAS 89-78-1) is a versatile compound with significant applications in medicine, cosmetics, and food industries, valued for its cooling effects and biological properties.
| Grade Standard | Industrial Grade |
| Purity | 99.0%min |
| Appearance | white pink blue red etc pure crystal |
| Application | wide usages |
| Melting point | 143°C (estimate) |
| Boiling point | 200 °C(lit.) |
| Density | 0.892 g/mL at 25 °C(lit.) |
| Flash point | 190 °F |
| Refractive index | n20/D 1.502(lit.) |
| Storage | Store below +30°C. |
| pKa | 9.77±0.19 |
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